Oral exposure of pregnant rats to toxic doses of methylmercury alters fetal accumulation

Abstract

Methylmercury (CH₃Hg⁺) is an environmental toxicant that may lead to significant pathologies in exposed individuals. The current study assessed the disposition and toxicological effects of 2.5 or 7.5mgkg^-1 CH₃Hg⁺, conjugated to cysteine (Cys; Cys-S-CH₃Hg) and administered orally to pregnant and non-pregnant Wistar and TR^- rats. Rats were euthanized on gestational day 20 and the content of mercury in each fetus, amniotic sac, and placenta was determined. The brain, liver, and kidneys were removed from each fetus for estimation of mercury content. From the dams, a sample of blood, kidneys, liver, and brain were removed at the time of euthanasia. The findings from this study indicate that pregnancy leads to significant changes in the handling of mercuric ions, particularly in the liver. Furthermore, there are significant differences in the handling of non-nephrotoxic and nephrotoxic doses of Cys-S-CH₃Hg by maternal and fetal organs.

Keywords: Fetus; Mercury; Metals; Methylmercury; Placenta.