Autologous and Allogeneic Hematopoietic Cell Transplantation in Peripheral T/NK-cell Lymphomas: A Histology-Specific Review

Tejaswini M Dhawale; Andrei R Shustov

doi:10.1016/j.hoc.2016.11.003

Autologous and Allogeneic Hematopoietic Cell Transplantation in Peripheral T/NK-cell Lymphomas: A Histology-Specific Review

Hematol Oncol Clin North Am. 2017 Apr;31(2):335-357. doi: 10.1016/j.hoc.2016.11.003.

Authors

Tejaswini M Dhawale¹, Andrei R Shustov²

Affiliations

¹ Department of Medicine, University of Washington School of Medicine, SCCA, 825 Eastlake Avenue East, M-Box G3-200, Seattle, WA 98109, USA.
² Department of Medicine, University of Washington School of Medicine, SCCA, 825 Eastlake Avenue East, M-Box G3-200, Seattle, WA 98109, USA. Electronic address: ashustov@seattlecca.org.

PMID: 28340882
DOI: 10.1016/j.hoc.2016.11.003

Abstract

Peripheral T-cell lymphoma and natural killer/T-cell lymphomas (PT/NKCL) make up a diverse subgroup of non-Hodgkin's lymphomas characterized by an aggressive clinical course. The use of hematopoietic stem cell transplantation (HSCT) in the treatment of PT/NKCL remains controversial because of the absence of randomized controlled trials. The best available data suggest that certain subtypes of PT/NKCL may benefit more from the application of HSCT than other subtypes and that this benefit results from their unique clinical characteristics and underlying biology. Ultimately, however, prospective randomized controlled trials are needed to clarify the optimal type and timing of HSCT in patients with PT/NKCL.

Keywords: Hematopoietic stem cell transplantation; Histology; Molecular biology; Natural killer/T-cell lymphoma; Pathophysiology; Peripheral T-cell lymphoma; Treatment.

Publication types

Review

MeSH terms

Allografts
Autografts
Hematopoietic Stem Cell Transplantation*
Lymphoma, Extranodal NK-T-Cell* / classification
Lymphoma, Extranodal NK-T-Cell* / pathology
Lymphoma, Extranodal NK-T-Cell* / therapy