Validity of a New Kit Measuring Salivary Lactate Dehydrogenase Level for Screening Gingivitis

Dis Markers. 2017:2017:9547956. doi: 10.1155/2017/9547956. Epub 2017 Feb 26.

Abstract

Aim. The aim of this study was to determine the usefulness of a new kit that can evaluate salivary lactate dehydrogenase (LD) level in real time for screening gingivitis. Materials and Methods. The study included 70 systemic healthy volunteers [29 males and 41 females; mean age ± SD: 24.1 ± 2.6 years]. Resting saliva was collected from each participant and LD level was evaluated in real time using the kit (a color-changing sheet with an integer scale ranging from 1 to 10). A dentist measured probing pocket depth, clinical attachment level, and the proportion of sites with bleeding on probing (% BOP) at six sites on all teeth. Gingivitis was diagnosed when the BOP value was ≥20%. Results. Salivary LD level was positively correlated with mean % BOP (odds ratio: 1.47, 95% confidence interval: 1.132-1.916, and P < 0.001) in a logistic regression model. The sensitivity and specificity of the kit were 0.89 and 0.98, respectively, at a cut-off value of 8.0 for LD level. Conclusions. The new kit for measurement of salivary LD level may be a useful tool to screen for gingivitis in young adults, which contributes to early detection of future periodontitis.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Gingivitis / diagnosis*
  • Humans
  • L-Lactate Dehydrogenase / analysis*
  • Male
  • Reagent Kits, Diagnostic / standards*
  • Saliva / chemistry*
  • Sensitivity and Specificity

Substances

  • Reagent Kits, Diagnostic
  • L-Lactate Dehydrogenase