Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds

Cijun Shuai; Chenying Shuai; Pei Feng; Youwen Yang; Yong Xu; Tian Qin; Sheng Yang; Chengde Gao; Shuping Peng

doi:10.3390/molecules22040511

Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds

Molecules. 2017 Mar 23;22(4):511. doi: 10.3390/molecules22040511.

Authors

Cijun Shuai^{1

2

3

4}, Chenying Shuai⁵, Pei Feng^{6

7}, Youwen Yang^{8

9}, Yong Xu¹⁰, Tian Qin¹¹, Sheng Yang¹², Chengde Gao^{13

14}, Shuping Peng^{15

16}

Affiliations

¹ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. shuai@csu.edu.cn.
² The State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China. shuai@csu.edu.cn.
³ Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha 410008, China. shuai@csu.edu.cn.
⁴ State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China. shuai@csu.edu.cn.
⁵ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. shuaichenying@csu.edu.cn.
⁶ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. fengpei@csu.edu.cn.
⁷ The State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China. fengpei@csu.edu.cn.
⁸ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. yangyouwen@csu.edu.cn.
⁹ State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China. yangyouwen@csu.edu.cn.
¹⁰ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. xuyong2927@csu.edu.cn.
¹¹ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. qintian@csu.edu.cn.
¹² Human Reproduction Center, Shenzhen Hospital of Hongkong University, Shenzhen 518053, China. tobyys2000@aliyun.com.
¹³ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. gaochengde@csu.edu.cn.
¹⁴ The State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China. gaochengde@csu.edu.cn.
¹⁵ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China. gaochengde@csu.edu.cn.
¹⁶ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China. gaochengde@csu.edu.cn.

Abstract

Diopside (DIOP) was introduced into polyetheretherketone/polyglycolicacid (PEEK/PGA) scaffolds fabricated via selective laser sintering to improve bioactivity. The DIOP surface was then modified using a silane coupling agent, 3-glycidoxypropyltrimethoxysilane (KH570), to reinforce interfacial adhesion. The results showed that the tensile properties and thermal stability of the scaffolds were significantly enhanced. It could be explained that, on the one hand, the hydrophilic group of KH570 formed an organic covalent bond with the hydroxy group on DIOP surface. On the other hand, there existed relatively high compatibility between its hydrophobic group and the biopolymer matrix. Thus, the ameliorated interface interaction led to a homogeneous state of DIOP dispersion in the matrix. More importantly, an in vitro bioactivity study demonstrated that the scaffolds with KH570-modified DIOP (KDIOP) exhibited the capability of forming a layer of apatite. In addition, cell culture experiments revealed that they had good biocompatibility compared to the scaffolds without KDIOP. It indicated that the scaffolds with KDIOP possess potential application in tissue engineering.

Keywords: bioactivity; diopside; interface adhesion; scaffolds; silane coupling agent.

MeSH terms

Cell Line
Humans
Silanes / chemical synthesis*
Silanes / chemistry
Silicic Acid / chemistry*
Surface Properties

Substances

Silanes
Silicic Acid
diopside