Gabapentin-induced aquagenic wrinkling of the palms

Dermatol Online J. 2017 Jan 15;23(1):13030/qt64k739q5.

Abstract

Aquagenic keratoderma (AK) or aquagenic wrinklingis a rare palmoplantar skin disease. It is sporadic orhereditary condition. It appears in childhood or youngadulthood and it is seen as multiple asymptomaticsmall shiny papules on the peripheral margin ofpalms and/or soles after submersion in water. Thepathogenesis and etiology of ASA remains unclear.Drugs sometimes trigger AK. Herein, we present thecase of a 29-year-old man who had begun treatmentwith gabapentin three weeks before the onset of hiscutaneous symptoms.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amines / adverse effects*
  • Analgesics / adverse effects*
  • Cyclohexanecarboxylic Acids / adverse effects*
  • Gabapentin
  • Hand Dermatoses / etiology*
  • Humans
  • Male
  • Neuralgia / drug therapy*
  • Skin
  • Water*
  • gamma-Aminobutyric Acid / adverse effects*

Substances

  • Amines
  • Analgesics
  • Cyclohexanecarboxylic Acids
  • Water
  • gamma-Aminobutyric Acid
  • Gabapentin