Metastatic neuroendocrine carcinoma in the skin

Dermatol Online J. 2017 Jan 15;23(1):13030/qt9052w9x1.

Abstract

Cutaneous metastases secondary to neuroendocrinetumors are rare. Herein we report a case of a 75-yearoldwoman who presented with a rare cutaneousmetastatic disease. She was previously diagnosed withmetastatic neuroendocrine carcinoma of unknownprimary, with metastases to liver, lung, and bone.Biopsy of the skin lesion demonstrated archetypicalpathology and positive immunohistochemicalstaining for chromogranin A and synaptophysin. Thepatient started palliative chemo-radiation therapyand passed away soon after.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Neoplasms / secondary*
  • Carcinoma, Neuroendocrine / metabolism
  • Carcinoma, Neuroendocrine / pathology
  • Carcinoma, Neuroendocrine / secondary*
  • Female
  • Humans
  • Immunohistochemistry
  • Liver Neoplasms / secondary*
  • Lung Neoplasms / secondary*
  • Neoplasms, Unknown Primary* / metabolism
  • Neoplasms, Unknown Primary* / pathology
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology
  • Skin Neoplasms / secondary*