Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform

Li-Sen Lin; Xiangyu Yang; Zijian Zhou; Zhen Yang; Orit Jacobson; Yijing Liu; Angela Yang; Gang Niu; Jibin Song; Huang-Hao Yang; Xiaoyuan Chen

doi:10.1002/adma.201606681

Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform

Adv Mater. 2017 Jun;29(21). doi: 10.1002/adma.201606681. Epub 2017 Mar 22.

Authors

Li-Sen Lin^{1

2}, Xiangyu Yang², Zijian Zhou², Zhen Yang², Orit Jacobson², Yijing Liu², Angela Yang², Gang Niu², Jibin Song², Huang-Hao Yang¹, Xiaoyuan Chen²

Affiliations

¹ The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
² Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

PMID: 28328150
DOI: 10.1002/adma.201606681

Abstract

Magnetic-plasmonic hybrid nanoparticles (MPHNs) have attracted great interest in cancer theranostics. However, the relaxivity of the magnetic component is typically reduced by the plasmonic component in conventional core-shell structured MPHNs, due to the presence of a water-impenetrable coating which severely restricts the proximity of protons to the magnetic portion. To circumvent this issue, yolk-shell structured MPHNs comprising a Fe₃ O₄ core within a hollow cavity encircled by a porous Au outer shell are designed. As expected, the introduction of hollow cavity between the magnetic and plasmonic portions significantly prevents the decline in relaxivity of the Fe₃ O₄ core caused by the Au layer. Moreover, in addition to conferring high near-infrared absorption to plasmonic component, the hollow cavity and the pores in the outer shell can also provide a large storage space and release channels for anticancer drugs. Furthermore, the multicomponent nanoparticles (NPs) still have a compact size of less than 100 nm to ensure efficient tumor accumulation. Taken together, the yolk-shell Fe₃ O₄ @Au NPs can be regarded as an ideal magnetic-plasmonic theranostic platform for magnetic resonance/photoacoustic/positron emission tomography multimodal imaging and light-activated chemothermal synergistic therapy.

Keywords: harmonious integration; magnetic-plasmonic platforms; multimodal imaging; synergistic therapy; yolk-shell nanostructures.