Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS2-PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS2 nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS2-based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (H2O2) detection. More interestingly, MoS2-PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS2-based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL-1. Moreover, the detection limit was calculated to be 0.54 pg mL-1. The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS2-PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.
Keywords: Molybdenum disulfide; Prussian blue nanocubes; electrochemical sensor; label-free; nonenzymatic.