Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

Fitoterapia. 2017 Apr:118:126-131. doi: 10.1016/j.fitote.2017.03.003. Epub 2017 Mar 16.

Abstract

Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7±0.5 and 14.1±3.5μM, respectively.

Keywords: Acarbose (PubChem CID: 444254); Cowagarcinone E (PubChem CID: 11421303); Cowanin (PubChem CID: 11754819); Cowanol (PubChem CID: 101671063); Garcinia oblongifolia; Norcowanin (PubChem CID: 11518330); Oblongixanthone C (PubChem CID: 25209204); PTP1B; RK682 (PubChem CID: 54678922); Rubraxanthone (PubChem CID: 9953366); Type 2 diabetes; Xanthones; α-Glucosidase.

MeSH terms

  • Garcinia / chemistry*
  • Glycoside Hydrolase Inhibitors / chemistry
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Humans
  • Hypoglycemic Agents / chemistry*
  • Hypoglycemic Agents / isolation & purification
  • Molecular Structure
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
  • Xanthones / chemistry*
  • Xanthones / isolation & purification
  • alpha-Glucosidases / metabolism

Substances

  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Xanthones
  • PTPN1 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • alpha-Glucosidases