Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection

Emerg Infect Dis. 2017 Apr;23(4):702-704. doi: 10.3201/eid2304.160466.

Abstract

Ross River virus, a mosquitoborne alphavirus, causes epidemic polyarthritis in Australia and the Pacific region. We analyzed serum cytokine, chemokine, and growth factor levels in travelers returning to Germany from Australia. Serum samples showed elevated concentrations in the acute phase of the illness and, more pronounced, in the long-lasting convalescent phase.

Keywords: Australia; Ross River virus; arthralgia; arthritis; cytokines; mosquitoes; vector-borne infections; viruses.

MeSH terms

  • Adult
  • Aged
  • Alphavirus Infections / complications*
  • Alphavirus Infections / metabolism
  • Alphavirus Infections / virology*
  • Arthralgia / etiology*
  • Cytokines / blood*
  • Cytokines / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ross River virus*
  • Travel
  • Young Adult

Substances

  • Cytokines