In this paper, we consider the robust face recognition problem via iterative re-constrained group sparse classifier (IRGSC) with adaptive weights learning. Specifically, we propose a group sparse representation classification (GSRC) approach in which weighted features and groups are collaboratively adopted to encode more structure information and discriminative information than other regression based methods. In addition, we derive an efficient algorithm to optimize the proposed objective function, and theoretically prove the convergence. There are several appealing aspects associated with IRGSC. First, adaptively learned weights can be seamlessly incorporated into the GSRC framework. This integrates the locality structure of the data and validity information of the features into l2,p -norm regularization to form a unified formulation. Second, IRGSC is very flexible to different size of training set as well as feature dimension thanks to the l2,p -norm regularization. Third, the derived solution is proved to be a stationary point (globally optimal if p ≥ 1 ). Comprehensive experiments on representative data sets demonstrate that IRGSC is a robust discriminative classifier which significantly improves the performance and efficiency compared with the state-of-the-art methods in dealing with face occlusion, corruption, and illumination changes, and so on.