The Utility of 68Ga-PSMA PET/CT in Poorly Differentiated Metastatic Prostate Cancer

Clin Nucl Med. 2017 May;42(5):403-405. doi: 10.1097/RLU.0000000000001617.

Abstract

We aimed to emphasize how useful PSMA PET/CT findings can be while trying to restage prostate cancer after radical prostatectomy in the presence of low prostate-specific antigen values. A 64-year-old man with pT3b N1 M0 Gleason 7 adenocarcinoma of the prostate presented 5 years postoperatively with a palpable axillary mass, whereas his prostate-specific antigen was 0.08 ng/mL. Conventional imaging studies and histopathologic findings of the axillary mass biopsy revealed inconclusive results. Ga-PSMA PET/CT demonstrated PSMA-positive metastatic lesions, the largest one being located in the right axilla. This finding confirmed metastatic poorly differentiated prostate cancer, and androgen deprivation therapy was initiated.

Publication types

  • Case Reports

MeSH terms

  • Edetic Acid / analogs & derivatives
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Oligopeptides
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / pathology
  • Radiopharmaceuticals*

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • Organometallic Compounds
  • Radiopharmaceuticals
  • gallium 68 PSMA-11
  • Edetic Acid