Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum

Thanh Tra Nguyen; Bich Ngan Truong; Huong Doan Thi Mai; Marc Litaudon; Van Hung Nguyen; Thao Do Thi; Van Minh Chau; Van Cuong Pham

doi:10.1016/j.bmcl.2017.03.014

Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1665-1669. doi: 10.1016/j.bmcl.2017.03.014. Epub 2017 Mar 7.

Authors

Thanh Tra Nguyen¹, Bich Ngan Truong², Huong Doan Thi Mai³, Marc Litaudon⁴, Van Hung Nguyen³, Thao Do Thi⁵, Van Minh Chau³, Van Cuong Pham⁶

Affiliations

¹ Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
² Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: tbngan1977@yahoo.com.
³ Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
⁴ Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Univ. Paris-Sud, 91198 Gif-sur-Yvette, France.
⁵ Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
⁶ Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: phamvc@imbc.vast.vn.

PMID: 28318944
DOI: 10.1016/j.bmcl.2017.03.014

Abstract

Four new dammarane-type triterpenoids (1-4) and twelve known compounds (5-16) were isolated from the leaves of Viburnum sambucinum Reinw. ex Blume. Their structures were determined by spectral data analysis, including MS and 2D NMR. Cytotoxic activity evaluation in vitro against four cancer cell lines (KB, LU-1, HepG2 and MCF7) suggested that the octanor-dammarane derivatives were the main cytotoxic components of the leaves of V. sambucinum.

Keywords: Adoxaceae; Caprifoliaceae; Dammarane; Viburnum; Vibusambucin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Dammaranes
Drug Screening Assays, Antitumor
Humans
Neoplasms / drug therapy
Plant Leaves / chemistry
Triterpenes / chemistry*
Triterpenes / isolation & purification
Triterpenes / pharmacology*
Viburnum / chemistry

Substances

Antineoplastic Agents, Phytogenic
Triterpenes