Segmental Vitiligo

Nanja van Geel; Reinhart Speeckaert

doi:10.1016/j.det.2016.11.005

Segmental Vitiligo

Dermatol Clin. 2017 Apr;35(2):145-150. doi: 10.1016/j.det.2016.11.005.

Authors

Nanja van Geel¹, Reinhart Speeckaert²

Affiliations

¹ Department of Dermatology, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium. Electronic address: Nanja.vangeel@ugent.be.
² Department of Dermatology, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium.

PMID: 28317524
DOI: 10.1016/j.det.2016.11.005

Abstract

Segmental vitiligo is characterized by its early onset, rapid stabilization, and unilateral distribution. Recent evidence suggests that segmental and nonsegmental vitiligo could represent variants of the same disease spectrum. Observational studies with respect to its distribution pattern point to a possible role of cutaneous mosaicism, whereas the original stated dermatomal distribution seems to be a misnomer. Although the exact pathogenic mechanism behind the melanocyte destruction is still unknown, increasing evidence has been published on the autoimmune/inflammatory theory of segmental vitiligo.

Keywords: Classification; Halo nevi; Lines of blaschko; Mosaicism; Segmental; Segmental vitiligo; Surgical treatment; Vitiligo.

Publication types

Review

MeSH terms

Humans
Skin / pathology*
Vitiligo / classification
Vitiligo / diagnosis*
Vitiligo / pathology