Hyper-Assembly of Self-Assembled Glycoclusters Mediated by Specific Carbohydrate-Carbohydrate Interactions

Gengwei Yan; Takumi Yamaguchi; Tatsuya Suzuki; Saeko Yanaka; Sota Sato; Makoto Fujita; Koichi Kato

doi:10.1002/asia.201700202

Hyper-Assembly of Self-Assembled Glycoclusters Mediated by Specific Carbohydrate-Carbohydrate Interactions

Chem Asian J. 2017 May 4;12(9):968-972. doi: 10.1002/asia.201700202. Epub 2017 Apr 18.

Authors

Gengwei Yan^{1

2

3

4}, Takumi Yamaguchi^{2

3

4}, Tatsuya Suzuki^{2

4}, Saeko Yanaka^{2

4}, Sota Sato^{5

6

7}, Makoto Fujita⁷, Koichi Kato^{1

2

4}

Affiliations

¹ School of Physical Science, SOKENDAI (The Graduate University for Advanced Studies), 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan.
² Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan.
³ School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, 923-1292, Japan.
⁴ Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
⁵ Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan.
⁶ JST, ERATO, Isobe Degenerate π-Integration Project, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan.
⁷ School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

PMID: 28317269
DOI: 10.1002/asia.201700202

Abstract

Hybridization of a self-assembled, spherical complex with oligosaccharides containing Lewis X, a functional trisaccharide displayed on various cell surfaces, yielded well-defined glycoclusters. The self-assembled glycoclusters exhibited homophilic hyper-assembly in aqueous solution in a Ca²⁺ -dependent manner through specific carbohydrate-carbohydrate interactions, offering a structural scaffold for functional biomimetic systems.

Keywords: NMR spectroscopy; carbohydrate-carbohydrate interactions; carbohydrates; glycoclusters; oligosaccharides; supramolecular chemistry.

MeSH terms

Carbohydrates / chemistry*
Glycoconjugates / chemical synthesis*
Glycoconjugates / chemistry
Molecular Structure
Oligosaccharides / chemistry

Substances

Carbohydrates
Glycoconjugates
Oligosaccharides