Objective: To explore the clinical characteristics, surgical procedures and prognosis of solid pseudopapillary tumor of the pancreas(SPTP). Methods: The clinical and follow-up data of 55 cases with SPTP in Henan Tumor Hospital from June 2005 to April 2015 were retrospectively analyzed. Results: There were 55 SPTP cases, including 7 males and 48 females. The age ranged from 16 to 76 (median, 33). Clinical presentations of SPTP were not specific. The mean size of the tumor was 7.6 cm (range from 2 to 25cm). Pancreatic head and tail were the most common locations of SPTP. All the patients received surgical resection with a definitive pathological diagnosis. Some immunohistochemical markers were mostly positive, including β-catenin, Vim, Syn, CD10, CD56, PR, etc. With a median follow-up of 53 months, the 1-year, 2-year and 5-year survival rate were 98.1%, 96.1% and 94.0%, respectively. Conclusions: SPTP is an uncommon exocrine pancreatic neoplasm with low malignant potential, which frequently occurs in young women. Preoperative imaging can provide evidence for the selection of treatment modalities among which surgical resection ispreferred. Diagnosis still relies on pathology and immunohistochemistry.
目的： 探讨胰腺实性假乳头状肿瘤(SPTP)的临床特征、手术策略及预后。 方法： 回顾性分析郑州大学附属肿瘤医院2005年6月至2015年4月收治的55例SPTP患者的临床及随访资料。 结果： 55例SPTP患者中，男性7例，女性48例；年龄16～76岁，中位年龄33岁。SPTP的临床表现不特异。肿瘤直径为2～25 cm，平均直径7.6 cm。SPTP多分布于胰腺头尾两端。55例患者均行手术治疗，术后病理检查均证实为胰腺实性假乳头状瘤。免疫组化染色显示，β－catenin、Vim、Syn、CD10、CD56和孕激素受体等多呈阳性表达。全组患者中位随访53个月，1、2和5年生存率分别为98.1%、96.1%和94.0%。 结论： SPTP是一种少见的胰腺外分泌肿瘤，恶性程度低，好发于中青年女性，术前影像学检查有助于治疗方式的选择，手术切除是首选的治疗方法，确诊仍依赖于术后病理和免疫组化染色。.
Keywords: Clinical characteristics; Pancreatic neoplasms; Prognosis; Solid pseudopapillary tumor of the pancreas, SPTP; Surgical procedures.