APOL1: a case in point for replacing race with genetics

Kidney Int. 2017 Apr;91(4):768-770. doi: 10.1016/j.kint.2017.02.002.

Abstract

Ethnicity-specific differences in apolipoprotein L1 (APOL1) polymorphisms are associated with racial disparities in kidney transplantation outcomes. APOL1 genotyping may better help define graft outcome risk pre-transplantation; however, more research is needed.

Publication types

  • Comment

MeSH terms

  • Apolipoprotein L1
  • Apolipoproteins / genetics*
  • Donor Selection / methods*
  • Genetic Testing*
  • Genotype
  • Graft Survival
  • Humans
  • Kidney Transplantation* / adverse effects
  • Lipoproteins, HDL / genetics*
  • Phenotype
  • Polymorphism, Genetic*
  • Postoperative Complications / ethnology
  • Postoperative Complications / genetics
  • Racial Groups*
  • Risk Assessment
  • Risk Factors
  • Tissue Donors*
  • Treatment Outcome

Substances

  • APOL1 protein, human
  • Apolipoprotein L1
  • Apolipoproteins
  • Lipoproteins, HDL