Nuclear factor 1 (NF-1) binding sites in the genomes of human oncoviruses: a hypothetic role for reintegrated cellular origins of replication in malignant transformation

Med Hypotheses. 1988 Jan;25(1):27-9. doi: 10.1016/0306-9877(88)90042-4.

Abstract

We have found that genomes of human T cell leukemia-lymphoma virus type I (HTLV-I), BK virus (BKV), and a hepatitis B virus (HBV) DNA sequence integrated into DNA of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (NF-1), a cellular protein which binds to adenoviral and putative cellular origins of DNA replication. We suggest that cellular origins of DNA replication acquired by oncoviruses may play a role in malignant transformation after reintegration into the cellular genome by providing new targets for cellular factors initiating DNA replication and by perturbing the temporal order of replication.

MeSH terms

  • Binding Sites
  • CCAAT-Enhancer-Binding Proteins*
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • DNA Replication*
  • DNA, Viral / genetics*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Deltaretrovirus / genetics
  • Hepatitis B virus / genetics
  • Humans
  • NFI Transcription Factors
  • Nuclear Proteins
  • Oncogenic Viruses / genetics*
  • Papillomaviridae / genetics
  • Polyomaviridae
  • Sequence Homology, Nucleic Acid
  • Transcription Factors*
  • Y-Box-Binding Protein 1

Substances

  • CCAAT-Enhancer-Binding Proteins
  • DNA, Viral
  • DNA-Binding Proteins
  • NFI Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Y-Box-Binding Protein 1
  • YBX1 protein, human