NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization

L F Pinto; I Marín-Montesinos; V Lloveras; J L Muñoz-Gómez; M Pons; J Veciana; J Vidal-Gancedo

doi:10.1039/c7cc00635g

NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization

Chem Commun (Camb). 2017 Mar 28;53(26):3757-3760. doi: 10.1039/c7cc00635g.

Authors

L F Pinto¹, I Marín-Montesinos², V Lloveras¹, J L Muñoz-Gómez¹, M Pons², J Veciana¹, J Vidal-Gancedo¹

Affiliations

¹ Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Bellaterra, Spain. j.vidal@icmab.es and CIBER-BBN, Barcelona, Spain.
² Biomolecular NMR laboratory, Inorganic and Organic Chemistry Department, University of Barcelona, Baldiri Reixac 10-12, 08028, Barcelona, Spain.

PMID: 28304028
DOI: 10.1039/c7cc00635g

Abstract

Herein, we report the synthesis and the study of a novel mixed biradical with BDPA and TEMPO radical units that are covalently bound by an ester group (BDPAesterTEMPO) as a polarizing agent for fast dissolution DNP. The biradical exhibits an extremely high DNP NMR enhancement of >50 000 times, which constitutes one of the largest signal enhancements observed so far, to the best of our knowledge.