miR-155 as a potential target of IL-3 signaling in primary AML cells

Leuk Res. 2017 Jun:57:57-59. doi: 10.1016/j.leukres.2017.02.010. Epub 2017 Mar 4.

Abstract

miR-155 has emerged as one of the key microRNAs (miRNAs) involved in normal and malignant myelopoiesis, and high expression of this miRNA has been flagged as a strong independent prognostic marker in Acute Myeloid Leukemia (AML). While elevated expression of miR-155 has been associated with FLT3-ITD mutations, other mechanisms which may regulate expression of this miRNA in AML remain largely unknown. Here, we present new evidence that miR-155 may be a prime target of IL-3 signaling in primary AML cells. This finding, together with the increasingly apparent role for miR-155 in oncogenesis, and the upregulation of the IL-3 receptor alpha subunit in AML, lead us to propose this pathway may significantly contribute to the leukemic transformation.

Keywords: AML; interleukin-3; miR-155.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Leukemic
  • Humans
  • Interleukin-3 / metabolism*
  • Interleukin-3 Receptor alpha Subunit / genetics
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / metabolism*
  • MicroRNAs / metabolism*
  • Signal Transduction*
  • Tumor Cells, Cultured
  • Up-Regulation

Substances

  • IL3 protein, human
  • IL3RA protein, human
  • Interleukin-3
  • Interleukin-3 Receptor alpha Subunit
  • MIRN155 microRNA, human
  • MicroRNAs