Abstract
Drosophila genetic studies demonstrate that cell and tissue growth regulation is a primary developmental function of P-element somatic inhibitor (Psi), the sole ortholog of FUBP family RNA/DNA-binding proteins. Psi achieves growth control through interaction with Mediator, observations that should put to rest controversy surrounding Pol II transcriptional functions for these KH domain proteins.
Keywords:
Drosophila; FUBP1; Growth control; MYC; Psi.
Publication types
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Review
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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DNA Helicases* / genetics
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DNA Helicases* / metabolism
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Drosophila
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Drosophila Proteins* / genetics
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Drosophila Proteins* / metabolism
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Nuclear Proteins* / genetics
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Nuclear Proteins* / metabolism
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Protein Domains
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RNA-Binding Proteins* / genetics
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RNA-Binding Proteins* / metabolism
Substances
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Drosophila Proteins
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Nuclear Proteins
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PSI protein, Drosophila
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RNA-Binding Proteins
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DNA Helicases