FUBP/KH domain proteins in transcription: Back to the future

Transcription. 2017 May 27;8(3):185-192. doi: 10.1080/21541264.2017.1293595. Epub 2017 Feb 16.

Abstract

Drosophila genetic studies demonstrate that cell and tissue growth regulation is a primary developmental function of P-element somatic inhibitor (Psi), the sole ortholog of FUBP family RNA/DNA-binding proteins. Psi achieves growth control through interaction with Mediator, observations that should put to rest controversy surrounding Pol II transcriptional functions for these KH domain proteins.

Keywords: Drosophila; FUBP1; Growth control; MYC; Psi.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Helicases* / genetics
  • DNA Helicases* / metabolism
  • Drosophila
  • Drosophila Proteins* / genetics
  • Drosophila Proteins* / metabolism
  • Nuclear Proteins* / genetics
  • Nuclear Proteins* / metabolism
  • Protein Domains
  • RNA-Binding Proteins* / genetics
  • RNA-Binding Proteins* / metabolism

Substances

  • Drosophila Proteins
  • Nuclear Proteins
  • PSI protein, Drosophila
  • RNA-Binding Proteins
  • DNA Helicases