Purpose: to study effect of norepinephrine reuptake blockade in reperfusion period on size of infarct caused by local ischemia with and without ischemic pre- and postconditioning.
Material and methods: Wistar rats (n=46) were randomly divided into 6 groups. Group (gr) I (n=7) - 30 min occlusion of left coronary artery followed by 120 reperfusion; gr II (n=2) as in gr I +desipramine (0.8 mg/kg intravenously [i.v.]) at the start of reperfusion; gr III (n=6) - ischemic preconditioning before coronary artery occlusion; gr IV (n=7).