Abstract
One new indole derivative, chloroindole (1), one new diketone, streptoone A (2), two new ketonic acids, streptoones B (3) and C (4), and one known macrolide antibiotic, X-14952B (5), were isolated from Streptomyces sp. SN0280. Extensive NMR, HRESIMS, and IR analysis was used to elucidate their structures. Streptoone A (2) displayed antibacterial activity (MIC value of 7.81 μg/mL) against Clavibater michiganensis, comparable with the positive control streptomycin (MIC value of 7.81 μg/mL). Streptoone B (3) showed antifungal activity (MIC value of 15.63 μg/mL) against Phytophthora capsici (positive control carbendazol MIC value of 7.81 μg/mL). These molecules provide new templates for the potential treatment and management of these phytopathogens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / pharmacology*
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Anti-Bacterial Agents / metabolism
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemistry
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Benzimidazoles / pharmacology
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Carbamates / pharmacology
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China
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / pharmacology*
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Macrolides / metabolism
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phytophthora / drug effects
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Soil Microbiology
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Streptomyces / chemistry*
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Benzimidazoles
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Carbamates
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Indoles
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Macrolides
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antibiotic X 14952B
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carbendazim