Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead

Curr Med Chem. 2019;26(8):1311-1327. doi: 10.2174/0929867324666170309124327.

Abstract

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

Keywords: Green synthesis; bio-imaging; biocompatibility; cancer; nanoparticles; theranostics..

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods
  • Ferritins / chemistry
  • Ferritins / therapeutic use
  • Gold / chemistry
  • Gold / therapeutic use
  • Green Chemistry Technology / methods*
  • Humans
  • Models, Molecular
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use*
  • Nanotechnology / methods
  • Neoplasms / diagnosis*
  • Neoplasms / therapy*
  • Quantum Dots / chemistry
  • Quantum Dots / therapeutic use
  • Selenium / chemistry
  • Selenium / therapeutic use
  • Serum Albumin, Human / chemistry
  • Serum Albumin, Human / therapeutic use
  • Silver / chemistry
  • Silver / therapeutic use
  • Theranostic Nanomedicine / methods*

Substances

  • Silver
  • Gold
  • Ferritins
  • Selenium
  • Serum Albumin, Human