Wnt/PCP Instructions for Cilia in Left-Right Asymmetry

Jun Wu; Marek Mlodzik

doi:10.1016/j.devcel.2017.02.023

Wnt/PCP Instructions for Cilia in Left-Right Asymmetry

Dev Cell. 2017 Mar 13;40(5):423-424. doi: 10.1016/j.devcel.2017.02.023.

Authors

Jun Wu¹, Marek Mlodzik²

Affiliations

¹ Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA.
² Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA. Electronic address: marek.mlodzik@mssm.edu.

Abstract

Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientation within the epithelial plane, but whether Wnts are instructive or permissive is debated. Reporting in Developmental Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left-right asymmetry establishment.

Publication types

Comment

MeSH terms

Animals
Cell Polarity*
Cilia*
Mice
Signal Transduction
Wnt Proteins

Substances

Wnt Proteins

Abstract

Publication types

MeSH terms

Substances

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