An endogenous ligand for phencyclidine receptors: isolated from human brains

NIDA Res Monogr. 1986:75:161-4.

Abstract

Using preparative HPLC, Sephadex G-25 and analytic HPLC, we obtained an active peak inhibiting (3H) PCP receptor binding, with a molecular weight of 3,000 daltons. Another isolation process included acetic acid extraction, Toyopearl HW gel filtration, Sephadex G-10 chromatography and analytic HPLC. An active peak was also observed, which was consistent with that from the first isolation process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / metabolism*
  • Humans
  • Ligands
  • Molecular Weight
  • Receptors, Neurotransmitter / metabolism*
  • Receptors, Opioid / metabolism*
  • Receptors, Phencyclidine
  • Tissue Extracts / metabolism

Substances

  • Ligands
  • Receptors, Neurotransmitter
  • Receptors, Opioid
  • Receptors, Phencyclidine
  • Tissue Extracts