A cobalt(ii) complex with unique paraSHIFT responses to anions

E S O'Neill; J L Kolanowski; P D Bonnitcha; E J New

doi:10.1039/c7cc00619e

A cobalt(ii) complex with unique paraSHIFT responses to anions

Chem Commun (Camb). 2017 Mar 23;53(25):3571-3574. doi: 10.1039/c7cc00619e.

Authors

E S O'Neill¹, J L Kolanowski¹, P D Bonnitcha², E J New¹

Affiliations

¹ School of Chemistry, The University of Sydney, NSW 2006, Australia. elizabeth.new@sydney.edu.au.
² Sydney Medical School, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia.

PMID: 28288215
DOI: 10.1039/c7cc00619e

Abstract

ParaSHIFT agents have shown promise in detecting chemical targets in biological systems by magnetic resonance, but few studies have used transition metal complexes for this purpose. Here we report our investigations into CoMe₆trenCl (tren = tris(2-aminoethyl)amine) as a paraSHIFT agent. The paramagnetic region of the ¹H NMR spectrum shows characteristic spectral profiles in the presence of fluoride, acetate, lactate and citrate in aqueous solution. These distinctive NMR shifts of each anion are maintained even in mixtures of anions.