Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors

Simone Maschauer; Jürgen Einsiedel; Dominik Reich; Harald Hübner; Peter Gmeiner; Hans-Jürgen Wester; Olaf Prante; Johannes Notni

doi:10.3390/ph10010029

Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors

Pharmaceuticals (Basel). 2017 Mar 10;10(1):29. doi: 10.3390/ph10010029.

Authors

Simone Maschauer¹, Jürgen Einsiedel², Dominik Reich³, Harald Hübner⁴, Peter Gmeiner⁵, Hans-Jürgen Wester⁶, Olaf Prante⁷, Johannes Notni⁸

Affiliations

¹ Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054 Erlangen, Germany. simone.maschauer@uk-erlangen.de.
² Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schuhstraße 19, 91052 Erlangen, Germany. rgen.einsiedel@fau.de.
³ Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meißner-Strasse 3, 85748 Garching, Germany. dominik.reich@tum.de.
⁴ Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schuhstraße 19, 91052 Erlangen, Germany. bner@fau.de.
⁵ Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schuhstraße 19, 91052 Erlangen, Germany. peter.gmeiner@fau.de.
⁶ Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meißner-Strasse 3, 85748 Garching, Germany. h.j.wester@tum.de.
⁷ Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054 Erlangen, Germany. olaf.prante@uk-erlangen.de.
⁸ Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meißner-Strasse 3, 85748 Garching, Germany. johannes.notni@tum.de.

Abstract

Neurotensin receptor 1 (NTS1) is overexpressed on a variety of cancer entities; for example, prostate cancer, ductal pancreatic adenocarcinoma, and breast cancer. Therefore, it represents an interesting target for the diagnosis of these cancers types by positron emission tomography (PET) [...].

Keywords: NTS1; PET; TRAP; gallium68; multimerization; neurotensin; neurotensin receptor; positron emission tomography.