The molecular biology of pelvi-ureteric junction obstruction

Pediatr Nephrol. 2018 Apr;33(4):553-571. doi: 10.1007/s00467-017-3629-0. Epub 2017 Mar 13.

Abstract

Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consider the known molecular mechanisms underpinning PUJO and review the potential of utilising this information to develop novel therapeutics and diagnostic biomarkers to improve the care of children with this disorder.

Keywords: Aetiology; Biomarker; Hydronephrosis; Molecular biology; Pelvi-ureteric junction obstruction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism*
  • Genetic Predisposition to Disease
  • Humans
  • Hydronephrosis / congenital*
  • Hydronephrosis / genetics
  • Hydronephrosis / metabolism
  • Hydronephrosis / therapy
  • Kidney Pelvis / pathology
  • Molecular Biology
  • Molecular Targeted Therapy / methods
  • Multicystic Dysplastic Kidney / genetics
  • Multicystic Dysplastic Kidney / metabolism*
  • Multicystic Dysplastic Kidney / therapy
  • Mutation
  • Ureter / pathology
  • Ureteral Obstruction / genetics
  • Ureteral Obstruction / metabolism*
  • Ureteral Obstruction / therapy

Substances

  • Biomarkers

Supplementary concepts

  • Multicystic renal dysplasia, bilateral