Interferon-I: The Pièce de Résistance of HIV-1 Transmission?

Damien C Tully; Daniel T Claiborne; Todd M Allen

doi:10.1016/j.tim.2017.02.010

Interferon-I: The Pièce de Résistance of HIV-1 Transmission?

Trends Microbiol. 2017 May;25(5):332-334. doi: 10.1016/j.tim.2017.02.010. Epub 2017 Mar 9.

Authors

Damien C Tully¹, Daniel T Claiborne¹, Todd M Allen²

Affiliations

¹ Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
² Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address: tallen2@mgh.harvard.edu.

Abstract

Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons.

Keywords: Bottleneck; HIV; Interferon; Mucosal; Resistance; Transmission.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Genetic Variation
HIV Infections / immunology*
HIV Infections / transmission*
HIV Infections / virology
HIV-1 / genetics
HIV-1 / immunology
HIV-1 / physiology*
Humans
Interferon Type I / immunology*
Mucous Membrane / immunology
Mucous Membrane / virology
Phylogeny
Selection, Genetic

Substances

Interferon Type I

Grants and funding

P01 AI104715/AI/NIAID NIH HHS/United States