Catalytic topological insulator Bi2Se3 nanoparticles for invivo protection against ionizing radiation

Xiao-Dong Zhang; Yaqi Jing; Shasha Song; Jiang Yang; Jun-Ying Wang; Xuhui Xue; Yuho Min; Gyeongbae Park; Xiu Shen; Yuan-Ming Sun; Unyong Jeong

doi:10.1016/j.nano.2017.02.018

Catalytic topological insulator Bi₂Se₃ nanoparticles for invivo protection against ionizing radiation

Nanomedicine. 2017 Jul;13(5):1597-1605. doi: 10.1016/j.nano.2017.02.018. Epub 2017 Mar 8.

Authors

Xiao-Dong Zhang¹, Yaqi Jing², Shasha Song³, Jiang Yang⁴, Jun-Ying Wang², Xuhui Xue³, Yuho Min⁵, Gyeongbae Park⁶, Xiu Shen³, Yuan-Ming Sun⁷, Unyong Jeong⁸

Affiliations

¹ Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, Tianjin, China; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China. Electronic address: xiaodongzhang@tju.edu.cn.
² Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, Tianjin, China.
³ Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
⁴ Environment, Energy and Natural Resources Center, Department of Environmental Science and Engineering, Fudan University, Shanghai, China.
⁵ Future Tech. Corporate R&D/LG Chem Research Park, Daejeon, Republic of Korea.
⁶ Department of Materials Science and Engineering, Cheongam-Ro 77, Pohang University of Science and Technology, Pohang, Republic of Korea.
⁷ Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. Electronic address: yuanmings1962@163.com.
⁸ Department of Materials Science and Engineering, Cheongam-Ro 77, Pohang University of Science and Technology, Pohang, Republic of Korea. Electronic address: ujeong@postech.ac.kr.

PMID: 28285158
DOI: 10.1016/j.nano.2017.02.018

Abstract

Bi₂Se₃ nanoparticles (NPs) have attracted wide interests in biological and medical applications. Layer-like Bi₂Se₃ with high active surface area is promising for free radical scavenging. Here, we extended the medical applications of Bi₂Se₃ NPs further to in vivo protection against ionizing radiation based on their superior antioxidant activities and electrocatalytic properties. It was found that Bi₂Se₃ NPs can significantly increase the surviving fraction of mice after exposure of high-energy radiation of gamma ray. Additionally, the Bi₂Se₃ NPs can help to recover radiation-lowered red blood cell counts, white blood cell counts and platelet levels. Further investigations revealed that Bi₂Se₃ NPs behaved as functional free radical scavengers and significantly decreased the level of methylenedioxyamphetamine. In vivo toxicity studies showed that Bi₂Se₃ NPs did not cause significant side effects in panels of blood chemistry, clinical biochemistry and pathology.

Keywords: Bi(2)Se(3); Free radical scavenging; Radiation protection.

MeSH terms

Animals
Catalysis
Free Radical Scavengers*
Gamma Rays
Mice
Nanoparticles*
Radiation, Ionizing*
Radiation-Protective Agents*

Substances

Free Radical Scavengers
Radiation-Protective Agents