Abnormality of regulatory T cells in common variable immunodeficiency

Gholamreza Azizi; Nasim Hafezi; Hamed Mohammadi; Reza Yazdani; Tina Alinia; Marzieh Tavakol; Asghar Aghamohammadi; Abbas Mirshafiey

doi:10.1016/j.cellimm.2016.12.007

Abnormality of regulatory T cells in common variable immunodeficiency

Cell Immunol. 2017 May:315:11-17. doi: 10.1016/j.cellimm.2016.12.007. Epub 2016 Dec 29.

Authors

Gholamreza Azizi¹, Nasim Hafezi², Hamed Mohammadi³, Reza Yazdani⁴, Tina Alinia⁵, Marzieh Tavakol⁶, Asghar Aghamohammadi⁷, Abbas Mirshafiey⁸

Affiliations

¹ Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
² Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
³ Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran.
⁷ Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: aghamohamadi@sina.tums.ac.ir.
⁸ Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mirshafiey@tums.ac.ir.

PMID: 28284485
DOI: 10.1016/j.cellimm.2016.12.007

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies (PAD) which is defined by recurrent infections, hypogammaglobulinemia and defects in B-cell differentiation into plasma cells and memory B cells. T cell abnormalities have also been described in CVID patients. Several studies reported that Treg frequencies and their functional characteristics are disturbed and might account for the aberrant immune responses observed in CVID patients. The aim of this review is to describe phenotypic and functional characteristics of Treg cells, and to review the literature with respect to the reported Treg defects and its association with the clinical manifestation in CVID.

Keywords: Common variable immunodeficiency; Regulatory T cells; T cell.

Publication types

Review

MeSH terms

B-Lymphocytes, Regulatory / immunology
B-Lymphocytes, Regulatory / pathology
Common Variable Immunodeficiency / immunology*
Common Variable Immunodeficiency / pathology
Common Variable Immunodeficiency / therapy
Humans
Immunoglobulins, Intravenous / therapeutic use
Lymphocyte Activation
Natural Killer T-Cells / immunology
Natural Killer T-Cells / pathology
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / pathology
T-Lymphocytes, Regulatory / classification
T-Lymphocytes, Regulatory / immunology
T-Lymphocytes, Regulatory / pathology*

Substances

Immunoglobulins, Intravenous