Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas

Thien Nguyen; Carlito Lagman; Lawrance K Chung; Cheng Hao Jacky Chen; Jessica Poon; Vera Ong; Brittany L Voth; Isaac Yang

doi:10.1016/j.jneuroim.2017.01.010

Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas

J Neuroimmunol. 2017 Apr 15:305:29-34. doi: 10.1016/j.jneuroim.2017.01.010. Epub 2017 Jan 18.

Authors

Thien Nguyen¹, Carlito Lagman², Lawrance K Chung¹, Cheng Hao Jacky Chen², Jessica Poon¹, Vera Ong², Brittany L Voth², Isaac Yang³

Affiliations

¹ Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
² Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States.
³ Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States; Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States; Department of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United States; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States. Electronic address: iyang@mednet.ucla.edu.

PMID: 28284342
DOI: 10.1016/j.jneuroim.2017.01.010

Abstract

Chemokine (C-C) motif ligand 21 (CCL21) is involved in immunosurveillance and has recently garnered the attention of neuro-oncologists and neuroscientists. CCL21 contains an extended C-terminus, which increases binding to lymphatic glycosaminoglycans and provides a mechanism for cell trafficking by forming a stationary chemokine concentration gradient that allows cell migration via haptotaxis. CCL21 is expressed by endothelial cells of the blood-brain barrier in physiologic and pathologic conditions. CCL21 has also been implicated in leukocyte extravasation into the central nervous system. In this review, we summarize the role of CCL21 in immunosurveillance and explore its potential as an immunotherapeutic agent for the treatment of gliomas.

Keywords: Blood-brain barrier; Chemokine CCL21; Exodus-2 chemokine; Glioma.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Neoplasms / immunology*
Brain Neoplasms / therapy*
Chemokine CCL21 / therapeutic use*
Glioma / immunology*
Glioma / therapy*
Humans
Immunotherapy / methods*
Monitoring, Immunologic*

Substances

CCL21 protein, human
Chemokine CCL21