Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection that may affect the brain. We investigated the role of indoleamine 2,3-dioxygenase (IDO-1/2) inhibition on long-term memory and energetic metabolism after experimental sepsis by caecal ligation and perforation (CLP). Experimental sepsis increased the activity of complexes I, II-III and IV at 24h after CLP, and IDO-1/2 inhibition normalized the activity of these complexes in the hippocampus. Wistar rats presented impairment of habituation and aversive memories 10days after CLP. Adjuvant treatment with the IDO inhibitor prevented long-term cognitive impairment triggered by sepsis.
Keywords:
Cognitive impairment; Energetic metabolism; Indoleamine 2,3-dioxygenase 1/2; Sepsis.
Copyright © 2017 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Avoidance Learning / drug effects
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Cognition Disorders / etiology*
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Cognition Disorders / metabolism*
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Cognition Disorders / prevention & control*
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Disease Models, Animal
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Energy Metabolism / drug effects
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Energy Metabolism / physiology*
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Exploratory Behavior / drug effects
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Hippocampus / drug effects
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Hippocampus / metabolism*
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Histocompatibility Antigens / metabolism
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Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism*
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Inhibition, Psychological
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Injections, Intra-Articular
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Male
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Rats
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Rats, Wistar
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Sepsis / complications*
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Sepsis / etiology
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Sepsis / microbiology
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Statistics, Nonparametric
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Sympathomimetics / pharmacology
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Sympathomimetics / therapeutic use
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p-Hydroxyamphetamine / pharmacology
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p-Hydroxyamphetamine / therapeutic use
Substances
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Histocompatibility Antigens
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Sympathomimetics
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p-Hydroxyamphetamine