Significance of MDR1 gene C3435T polymorphism in predicting childhood refractory epilepsy

Rui-Juan Lv; Xiao-Qiu Shao; Tao Cui; Qun Wang

doi:10.1016/j.eplepsyres.2017.02.010

Significance of MDR1 gene C3435T polymorphism in predicting childhood refractory epilepsy

Epilepsy Res. 2017 May:132:21-28. doi: 10.1016/j.eplepsyres.2017.02.010. Epub 2017 Feb 28.

Authors

Rui-Juan Lv¹, Xiao-Qiu Shao¹, Tao Cui¹, Qun Wang²

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing, PR China, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China.
² Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing, PR China, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China. Electronic address: qwang64@163.com.

PMID: 28284049
DOI: 10.1016/j.eplepsyres.2017.02.010

Abstract

The association between the MDR1 gene C3435T polymorphism and childhood intractable epilepsy remains controversial. In this study, we performed a meta-analysis to clarify this issue. We searched the PubMed, Medline, Embase and CNKI databases for studies published through October 2016 that evaluated the association between the MDR1 C3435T polymorphism and childhood refractory epilepsy. Eleven studies involving 863 cases in the group with drug-resistant epilepsy and 915 cases in the group with drug-responsive epilepsy were included in this systematic review and meta-analysis. The analysis showed that there was not a significant association of the MDR1 C3435T polymorphism overall with risk of drug-resistance. But the allelic association of MDR1 C3435T and the association of the MDR1 3435 CC genotype with risk of drug-resistance were significant among European population and a '>2010' group based on publication year subgroup analysis. The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.

Keywords: C3435T polymorphism; Childhood refractory epilepsy; Meta-analysis; Multi-drug resistance 1 gene.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B / genetics
Drug Resistance / genetics
Drug Resistance, Multiple / genetics
Epilepsy / genetics*
Gene Frequency / genetics
Genetic Predisposition to Disease*
Genotype
Humans
Polymorphism, Single Nucleotide / genetics*
White People

Substances

ABCB1 protein, human
ATP Binding Cassette Transporter, Subfamily B