Gel or Die: Phase Separation as a Survival Strategy

Sonja Kroschwald; Simon Alberti

doi:10.1016/j.cell.2017.02.029

Gel or Die: Phase Separation as a Survival Strategy

Cell. 2017 Mar 9;168(6):947-948. doi: 10.1016/j.cell.2017.02.029.

Authors

Sonja Kroschwald¹, Simon Alberti²

Affiliations

¹ Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
² Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address: alberti@mpi-cbg.de.

PMID: 28283065
DOI: 10.1016/j.cell.2017.02.029

Abstract

Stress conditions trigger protein assembly by demixing from the cytoplasm, but the biological significance is still unclear. In this issue of Cell, Riback et al. report that the yeast poly(A)-binding protein 1 (Pab1) is a phase-separating stress sensor that boosts organismal fitness under physiological stress conditions.

Publication types

Comment

MeSH terms

Cytoplasm / metabolism
Poly(A)-Binding Protein I / metabolism*
Poly(A)-Binding Proteins / metabolism
Proteins / metabolism
Saccharomyces cerevisiae / metabolism*

Substances

Poly(A)-Binding Protein I
Poly(A)-Binding Proteins
Proteins