Lymphocytic Meningitis in Patients with Sympathetic Ophthalmia

Ocul Immunol Inflamm. 2017 Apr;25(2):196-201. doi: 10.1080/09273948.2017.1291841. Epub 2017 Mar 10.

Abstract

Purpose: This study aimed at reporting lymphocytic meningitis in patients diagnosed with sympathetic ophthalmia (SO).

Methods: In this single-center retrospective observational case series, we reviewed cases diagnosed with SO. We analyzed the patients' inciting injuries, the characteristics of uveitis and the cerebrospinal fluid (CSF) analyses.

Results: Nine patients were diagnosed with SO and CSF analyses were available in all cases. Four cases had lymphocytic pleocytosis, 3 of which showed marked CSF inflammation with more than 300 lymphocytes/mm3. The inciting event in these 3 patients was a globe perforation injury, whereas 4 patients without meningitis had SO following a surgical intervention.

Conclusions: In this case series of patients with SO, lymphocytic meningitis was a common finding. The prevalence of meningitis in patients with SO and its value for the diagnosis of the disease needs to be further studied.

Keywords: Cerebrospinal fluid pleocytosis; lumbar puncture; meningitis; panuveitis; sympathetic ophthalmia.

MeSH terms

  • Adult
  • Aged
  • Female
  • Fluorescein Angiography
  • Humans
  • Leukocytosis / cerebrospinal fluid
  • Leukocytosis / diagnosis*
  • Lymphocytes / pathology*
  • Male
  • Meningitis / cerebrospinal fluid
  • Meningitis / diagnosis*
  • Middle Aged
  • Ophthalmia, Sympathetic / cerebrospinal fluid
  • Ophthalmia, Sympathetic / diagnosis*
  • Prevalence
  • Retrospective Studies
  • Spinal Puncture
  • Young Adult