Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09

Nat Prod Res. 2017 Aug;31(15):1819-1824. doi: 10.1080/14786419.2017.1295240. Epub 2017 Feb 28.

Abstract

An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited antifungal activities against Candida albicans with MIC of about 25.0 μg mL-1.

Keywords: Streptomyces antibioticus; antifungal activity; antimycin; kitamycin C.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Antimycin A / analogs & derivatives
  • Antimycin A / pharmacology
  • Candida albicans / drug effects
  • Drug Evaluation, Preclinical
  • Macrolides / chemistry*
  • Macrolides / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Spectrometry, Mass, Electrospray Ionization
  • Streptomyces antibioticus / chemistry*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Macrolides
  • kitamycin A
  • kitamycin C
  • urauchmycin B
  • antimycin
  • Antimycin A