Abstract
The present study investigated the chemical constituents of aerial part of Polygonum pubescens Blume. Twenty-two compounds 1-22 were obtained from petroleum ether and ethyl acetate extracts of aerial part of P. pubescens, including a new phenylpropanoide esters 1 and 21 known compounds. The structures were determined on the basis of spectroscopic and chemical methods. Sixteen compounds were assessed for their cytotoxic and anti-inflammatory activities. Several compounds showed effects on different targets.
Keywords:
Polygonum pubescens Blume; anti-inflammatory activity; chemical constituents; cytotoxic activity.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / pharmacology*
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Cell Line, Tumor
-
Cinnamates / chemistry
-
Cinnamates / isolation & purification
-
Cinnamates / pharmacology
-
Drug Evaluation, Preclinical / methods
-
Humans
-
Molecular Structure
-
NF-kappa B / antagonists & inhibitors
-
NF-kappa B / metabolism
-
Plant Extracts / chemistry*
-
Plant Extracts / pharmacology
-
Polygonum / chemistry*
Substances
-
Anti-Inflammatory Agents
-
Antineoplastic Agents, Phytogenic
-
Cinnamates
-
NF-kappa B
-
Plant Extracts
-
vanicoside A