Caspase inhibitors for the treatment of liver disease: friend or foe?

Expert Rev Gastroenterol Hepatol. 2017 May;11(5):397-399. doi: 10.1080/17474124.2017.1300060. Epub 2017 Mar 4.
No abstract available

Keywords: Apoptosis; TNF-alpha; acetaminophen; caspase inhibitors; cholestasis; galactosamine-endotoxin; hepatotoxicity; ischemia-reperfusion; necroptosis.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Apoptosis Regulatory Proteins / metabolism
  • Caspase Inhibitors / adverse effects
  • Caspase Inhibitors / therapeutic use*
  • Humans
  • Liver / drug effects*
  • Liver / enzymology
  • Liver / pathology
  • Liver Diseases / drug therapy*
  • Liver Diseases / enzymology
  • Liver Diseases / pathology
  • Risk Factors
  • Signal Transduction / drug effects
  • Treatment Outcome

Substances

  • Apoptosis Regulatory Proteins
  • Caspase Inhibitors