Identifying Natural syNergist from Pongamia pinnata Using High-Speed Counter-Current Chromatography Combined with Isobolographic Analysis

Hao Yin; Yubai Wei; Rouwen Chen; Si Zhang; Lijuan Long; Hang Yin; Xinpeng Tian; Weihong He

doi:10.3390/molecules22030397

Identifying Natural syNergist from Pongamia pinnata Using High-Speed Counter-Current Chromatography Combined with Isobolographic Analysis

Molecules. 2017 Mar 3;22(3):397. doi: 10.3390/molecules22030397.

Authors

Hao Yin^{1

2}, Yubai Wei^{3

4

5}, Rouwen Chen^{6

7

8}, Si Zhang^{9

10}, Lijuan Long^{11

12}, Hang Yin¹³, Xinpeng Tian^{14

15}, Weihong He^{16

17}

Affiliations

¹ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. yinhao@scsio.ac.cn.
² Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. yinhao@scsio.ac.cn.
³ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. ybwei@scsio.ac.cn.
⁴ Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. ybwei@scsio.ac.cn.
⁵ College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China. ybwei@scsio.ac.cn.
⁶ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. chenrouwen15@mails.ucas.ac.cn.
⁷ Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. chenrouwen15@mails.ucas.ac.cn.
⁸ College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China. chenrouwen15@mails.ucas.ac.cn.
⁹ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. zhsimd@scsio.ac.cn.
¹⁰ Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. zhsimd@scsio.ac.cn.
¹¹ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. longlj@scsio.ac.cn.
¹² Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. longlj@scsio.ac.cn.
¹³ College of Pharmacy, Guiyang, Guizhou 550001, China. yhem@21cn.com.
¹⁴ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. xinpengtian@scsio.ac.cn.
¹⁵ Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. xinpengtian@scsio.ac.cn.
¹⁶ Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. weihonghe@scsio.ac.cn.
¹⁷ Guangdong Key Laboratory of Marine Material Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. weihonghe@scsio.ac.cn.

Abstract

For identifying the synergistic compounds from Pongamia pinnata, an approach based on high-speed counter-current chromatography (HSCCC) combined with isobolographic analysis was designed to detect the synergistic effects in the complex mixture [...].

Keywords: Pongamia pinnata; chemical subtraction; high-speed counter-current chromatography (HSCCC); isobolographic analysis; natural synergists; subtracted residue.

MeSH terms

Countercurrent Distribution
Drug Synergism
Millettia / chemistry*
Phytochemicals / analysis*
Plant Extracts / chemistry*

Substances

Phytochemicals
Plant Extracts