Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)

A Gupta; G K Reddy; M Goyal; M R Kasaragadda

doi:10.4103/0022-3859.201413

Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)

J Postgrad Med. 2017 Jul-Sep;63(3):194-196. doi: 10.4103/0022-3859.201413.

Authors

A Gupta¹, G K Reddy², M Goyal¹, M R Kasaragadda¹

Affiliations

¹ Department of Hematopathology and Genetics, AMPATH, Nallagandla, Serilingampally Hyderabad, Telangana, India.
² Department of Medical Oncology, Manipal Super Specialty Hospital, Vijaywada, Andhra Pradesh, India.

Abstract

Erythrophagocytosis by leukemic blasts is a rare phenomenon. We report a case of a female diagnosed with acute monoblastic leukemia with leukemic blasts that were CD34 and CD117 negative, showing erythrophagocytosis, vacoulations, and a rare t(8;16) on bone marrow karyotype which is associated with a poor prognosis despite intensive chemotherapy. Meticulous bone marrow examination in such a scenario may point towards the presence of t(8;16) and help clinicians take a well-informed clinical decision.

Publication types

Case Reports

MeSH terms

Adult
Anemia, Refractory, with Excess of Blasts / mortality
Anemia, Refractory, with Excess of Blasts / pathology*
Bone Marrow / pathology*
Chromosome Aberrations
Fatal Outcome
Female
Humans
Karyotype
Leukemia, Myeloid, Acute / mortality
Leukemia, Myeloid, Acute / pathology*
Mutation