Automatic assessment of medication states of patients with Parkinson's disease using wearable sensors

Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug:2016:6082-6085. doi: 10.1109/EMBC.2016.7592116.

Abstract

Motor fluctuations are a major focus of clinical managements in patients with mid-stage and advance Parkinson's disease (PD). In this paper, we develop a new patient-specific algorithm that can classify those fluctuations during a variety of activities. We extract a set of temporal and spectral features from the ambulatory signals and then introduce a semi-supervised classification algorithm based on K-means and self-organizing tree map clustering methods. Two different types of cluster labeling are introduced: hard and fuzzy labeling. The developed algorithm is evaluated on a dataset from triaxial gyroscope sensors for 12 PD patients. The average result of using K-means and fuzzy labeling on the trunk and the more affected leg sensors' readings was 75.96%, 70.57%, and 86.93% for accuracy, sensitivity, and specificity, respectively. The accuracy for individual patients varied from 99.95% to 42.53%, which was correlated with dyskinesia severity and the improvement of the PD symptoms with medication.

MeSH terms

  • Algorithms
  • Clothing
  • Drug Monitoring
  • Dyskinesias / classification
  • Dyskinesias / physiopathology
  • Fuzzy Logic
  • Humans
  • Monitoring, Ambulatory / instrumentation*
  • Monitoring, Ambulatory / methods*
  • Parkinson Disease* / classification
  • Parkinson Disease* / diagnosis
  • Parkinson Disease* / drug therapy
  • Parkinson Disease* / physiopathology
  • Signal Processing, Computer-Assisted*