Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study

Marina Maintinguer Norde; Erica Oki; Antonio Augusto Ferreira Carioca; Nágila Raquel Teixeira Damasceno; Regina Mara Fisberg; Dirce Maria Lobo Marchioni; Marcelo Macedo Rogero

doi:10.1016/j.clnu.2017.02.009

Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study

Clin Nutr. 2018 Apr;37(2):659-666. doi: 10.1016/j.clnu.2017.02.009. Epub 2017 Feb 17.

Authors

Marina Maintinguer Norde¹, Erica Oki¹, Antonio Augusto Ferreira Carioca¹, Nágila Raquel Teixeira Damasceno¹, Regina Mara Fisberg¹, Dirce Maria Lobo Marchioni¹, Marcelo Macedo Rogero²

Affiliations

¹ Department of Nutrition, School of Public Health, University of Sao Paulo, Dr. Arnaldo Avenue 715, São Paulo 01246-904, Brazil.
² Department of Nutrition, School of Public Health, University of Sao Paulo, Dr. Arnaldo Avenue 715, São Paulo 01246-904, Brazil. Electronic address: mmrogero@usp.br.

PMID: 28268030
DOI: 10.1016/j.clnu.2017.02.009

Abstract

Background & aims: Metabolic syndrome (MetS) is a cluster of interrelated risk factors for type 2 diabetes mellitus, and cardiovascular disease, with underlying inflammatory pathophysiology. Genetic variations and diet are well-known risk factor for MetS, but the interaction between these two factors is less explored. The aim of the study was to evaluate the influence of interaction between SNP of inflammatory genes (encoding interleukin (IL)-6, IL-1β and IL-10) and plasma fatty acids on the odds of MetS, in a population-based cross-sectional study.

Methods: Among participants of the Health Survey - São Paulo, 301 adults (19-59 y) from whom a blood sample was collected were included. Individuals with and without MetS were compared according to their plasma inflammatory biomarkers, fatty acid profile, and genotype frequency of the IL1B (rs16944, rs1143623, rs1143627, rs1143634 and rs1143643), IL6 (rs1800795, rs1800796 and rs1800797) and IL10 (rs1554286, rs1800871, rs1800872, rs1800890 and rs3024490) genes SNP. The influence of gene-fatty acids interaction on MetS risk was investigated.

Results: IL6 gene SNP rs1800795 G allele was associated with higher odds for MetS (OR = 1.88; p = 0.017). Gene-fatty acid interaction was found between the IL1B gene SNP rs116944 and stearic acid (p inter = 0.043), and between rs1143634 and EPA (p inter = 0.017). For the IL10 gene SNP rs1800896, an interaction was found for arachidonic acid (p inter = 0.007) and estimated D5D activity (p inter = 0.019).

Conclusion: The IL6 gene SNP rs1800795 G allele is associated with increased odds for MetS. Plasma fatty acid profile interacts with the IL1B and IL10 gene variants to modulate the odds for MetS. This and other interactions of risk factors can account for the unexplained heritability of MetS, and their elucidation can lead to new strategies for genome-customized prevention of MetS.

Keywords: Fatty-acid; Gene; Interleukin; Metabolic syndrome; Polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Sectional Studies
Fatty Acids / blood*
Fatty Acids / genetics
Female
Genetic Predisposition to Disease
Humans
Interleukin-10 / blood
Interleukin-10 / genetics*
Interleukin-1beta / blood
Interleukin-1beta / genetics*
Interleukin-6 / blood
Interleukin-6 / genetics*
Male
Metabolic Syndrome / blood*
Metabolic Syndrome / genetics*
Middle Aged
Risk Factors

Substances

Fatty Acids
IL10 protein, human
IL1B protein, human
IL6 protein, human
Interleukin-1beta
Interleukin-6
Interleukin-10