Extracellular vesicles in lung cancer-From bench to bedside

Tsukasa Kadota; Yusuke Yoshioka; Yu Fujita; Kazuyoshi Kuwano; Takahiro Ochiya

doi:10.1016/j.semcdb.2017.03.001

Extracellular vesicles in lung cancer-From bench to bedside

Semin Cell Dev Biol. 2017 Jul:67:39-47. doi: 10.1016/j.semcdb.2017.03.001. Epub 2017 Mar 4.

Authors

Tsukasa Kadota¹, Yusuke Yoshioka², Yu Fujita³, Kazuyoshi Kuwano⁴, Takahiro Ochiya⁵

Affiliations

¹ Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: tkskdt@jikei.ac.jp.
² Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
³ Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
⁴ Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
⁵ Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan. Electronic address: tochiya@ncc.go.jp.

PMID: 28267596
DOI: 10.1016/j.semcdb.2017.03.001

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in lung cancer research and novel therapies, a better understanding of the disease is crucially needed to facilitate early detection and appropriate diagnoses and to improve treatment outcomes. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from all tested cell types and modulate cell-cell communication. EVs transfer a wide variety of molecules, such as proteins, messenger RNAs and microRNAs. Emerging data suggest that EVs play an important role in lung cancer pathogenesis and may have potential as biomarkers and therapeutics. Here, we review current research on EVs in lung cancer.

Keywords: Biomarker; Exosome; Extracellular vesicle; Lung cancer; Microenvironment; Therapy.

Publication types

Review

MeSH terms

Antineoplastic Agents / therapeutic use
Biomarkers / metabolism
Cancer-Associated Fibroblasts / metabolism
Cancer-Associated Fibroblasts / pathology
Cell Communication
Drug Resistance, Neoplasm / genetics
Epithelial-Mesenchymal Transition / genetics
Extracellular Vesicles / metabolism*
Extracellular Vesicles / pathology
Gene Expression Regulation, Neoplastic*
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism
Lung Neoplasms / pathology
Neoplasm Proteins / genetics*
Neoplasm Proteins / metabolism
Neovascularization, Pathologic / genetics
Neovascularization, Pathologic / metabolism*
Neovascularization, Pathologic / pathology
RNA, Neoplasm / genetics*
RNA, Neoplasm / metabolism
Signal Transduction
Translational Research, Biomedical / methods
Tumor Microenvironment / genetics

Substances

Antineoplastic Agents
Biomarkers
Neoplasm Proteins
RNA, Neoplasm