Imaging of Prostate Cancer Using 11C-Choline PET/Computed Tomography

PET Clin. 2017 Apr;12(2):137-143. doi: 10.1016/j.cpet.2016.11.002. Epub 2017 Jan 9.

Abstract

This article reviews the role of 11C-choline-PET/computed tomography (CT) in patients with prostate cancer for diagnosis, staging, and restaging the disease in case of biochemical recurrence after primary treatment. The main application of this imaging procedure is restaging of the disease in case of biochemical recurrence. 11C-Choline-PET/CT proved its value for metastases-directed salvage therapies and for monitoring therapy response in castration-resistant patients. Prostate-specific antigen and prostate-specific antigen kinetics values confirmed their correlation with 11C-choline PET/CT sensitivity.11C-CholinePET/CT, despite low sensitivity to stage disease or in case of biochemical failure with low PSA levels, has an important impact on the management of patients with prostate cancer.

Keywords: Choline PET/CT; Diagnosis; Prostate cancer; Staging.

Publication types

  • Review

MeSH terms

  • Carbon Radioisotopes*
  • Choline*
  • Early Detection of Cancer / methods
  • Humans
  • Male
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Staging
  • Positron Emission Tomography Computed Tomography / methods*
  • Prostate-Specific Antigen / metabolism
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms, Castration-Resistant / diagnostic imaging
  • Radiopharmaceuticals*
  • Salvage Therapy
  • Sensitivity and Specificity

Substances

  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • Prostate-Specific Antigen
  • Choline