Investigation of the Mesoporous Metal-Organic Framework as a New Platform To Study the Transport Phenomena of Biomolecules

Yao Chen; Seongmin Hong; Chung-Wei Fu; Tran Hoang; Xiao Li; Veronica Valencia; Zhenjie Zhang; Jason A Perman; Shengqian Ma

doi:10.1021/acsami.7b00588

Investigation of the Mesoporous Metal-Organic Framework as a New Platform To Study the Transport Phenomena of Biomolecules

ACS Appl Mater Interfaces. 2017 Mar 29;9(12):10874-10881. doi: 10.1021/acsami.7b00588. Epub 2017 Mar 16.

Authors

Yao Chen¹, Seongmin Hong², Chung-Wei Fu^{2

3}, Tran Hoang², Xiao Li², Veronica Valencia², Zhenjie Zhang^{1

4}, Jason A Perman², Shengqian Ma²

Affiliations

¹ State Key Laboratory of Medicinal Chemical Biology, Nankai University , Tianjin 300350, China.
² Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
³ Department of Chemistry, Chung Yuan Christian University , 200 Chung Pei Road, Chung-Li 320, Taiwan, ROC.
⁴ Department of Chemistry, Nankai University , Tianjin 300071, China.

PMID: 28263545
DOI: 10.1021/acsami.7b00588

Abstract

Mesoporous materials, Tb-mesoMOF and MCM-41, were used to study the transport phenomena of biomolecules entering the interior pores from solution. Vitamins B₁₂ and B₂ were successfully encapsulated into these mesoporous materials, whereas Tb-mesoMOF (0.33 g of B₁₂/g, 0.01 g of B₂/g) adsorbed a higher amount of vitamin per mass than MCM-41 (0.21 g of B₁₂/g, 0.002 g of B₂/g). The diffusion mechanism of the biomolecules entering Tb-mesoMOF was evaluated using a mathematical model. The Raman spectroscopy studies showed vitamin B₁₂ has been encapsulated within Tb-mesoMOF's pores, and evaluation of the peak shifts indicated strong interactions linking vitamin B₁₂'s pyrroline moiety with Tb-mesoMOF's triazine and benzoate rings. Because of these stronger interactions between the vitamins and Tb-mesoMOF, longer egress times were observed than with MCM-41.

Keywords: Raman spectroscopy; biomolecules; mesoporous metal−organic framework; transport phenomena; vitamin B12 and B2.