Isolation of a hexaprenylhydroquinone sulfate from the marine sponge Dysidea sp. as an H,K-ATPase inhibitor

N Fusetani; M Sugano; S Matsunaga; K Hashimoto; H Shikama; A Ohta; H Nagano

doi:10.1007/BF01945539

Isolation of a hexaprenylhydroquinone sulfate from the marine sponge Dysidea sp. as an H,K-ATPase inhibitor

Experientia. 1987 Dec 1;43(11-12):1233-4. doi: 10.1007/BF01945539.

Authors

N Fusetani¹, M Sugano, S Matsunaga, K Hashimoto, H Shikama, A Ohta, H Nagano

Affiliation

¹ Laboratory of Marine Biochemistry, Faculty of Agriculture, University of Tokyo, Japan.

PMID: 2826217
DOI: 10.1007/BF01945539

Abstract

A hexaprenylhydroquinone sulfate has been isolated as an H,K-ATPase inhibitor from a marine sponge Dysidea sp. It also inhibited phospholipase A2 as well as secretion of gastric acid in rats.

MeSH terms

Adenosine Triphosphatases / antagonists & inhibitors*
Animals
Chemical Phenomena
Chemistry
Gastric Acid / metabolism
Gastric Mucosa / drug effects
H(+)-K(+)-Exchanging ATPase
Magnetic Resonance Spectroscopy
Phospholipases A / antagonists & inhibitors
Phospholipases A2
Porifera / analysis*
Rats
Terpenes / isolation & purification*
Terpenes / pharmacology

Substances

Terpenes
hexaprenylhydroquinone sulfate
Phospholipases A
Phospholipases A2
Adenosine Triphosphatases
H(+)-K(+)-Exchanging ATPase