Muscle oxygen saturation increases during head-up tilt-induced (pre)syncope

Abstract

Aim: To evaluate whether muscle vasodilatation plays a role for hypotension developed during central hypovolaemia, muscle oxygenation (S_m O₂ ) was examined during (pre)syncope induced by head-up tilt (HUT). Skin blood flow (SkBF) and oxygenation (S_skin O₂ ) were determined because evaluation of S_m O₂ may be affected by superficial tissue oxygenation. Furthermore, we evaluated cerebral oxygenation (S_c O₂ ) and middle cerebral artery mean blood flow velocity (MCAv_mean ).

Methods: Twenty healthy male volunteers (median age 24 years; range 19-38) were subjected to passive 50° HUT for 1 h or until (pre)syncope. S_c O₂ and S_m O₂ (near-infrared spectroscopy), MCAv_mean (transcranial Doppler) along with mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and total peripheral resistance (TPR) (Modelflow^® ) were determined.

Results: (Pre)syncopal symptoms appeared in 17 subjects after 11 min (median; range 2-34) accompanied by a decrease in MAP, SV, CO and TPR, while HR remained elevated. During (pre)syncope, S_c O₂ decreased [73% (71-76; mean and 95% CI) to 68% (65-71), P < 0.0001] along with MCAv_mean [40 (37-43) to 32 (29-35) cm s^-1 , P < 0.0001]. In contrast, S_m O₂ increased [63 (56-69)% to 71% (65-78), P < 0.0001], while S_skin O₂ [64% (58-69) to 53% (47-58), P < 0.0001] and SkBF [71 (44-98) compared to a baseline of 99 (72-125) units, P = 0.020] were reduced.

Conclusion: We confirm that the decrease in MAP during HUT is associated with a reduction in indices of cerebral perfusion. (Pre)syncope was associated with an increase in S_m O₂ despite reduced S_skin O₂ and SkBF, supporting that muscle vasodilation plays an important role in the circulatory events leading to hypotension during HUT.

Keywords: cerebral blood flow; head-up tilt; muscle oxygenation; near-infrared spectroscopy; skin blood flow; syncope.