Abstract
One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.
MeSH terms
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Alginates / chemical synthesis
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Alginates / chemistry*
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Alginates / toxicity
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Biocompatible Materials / toxicity
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Boronic Acids / chemical synthesis
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Boronic Acids / chemistry*
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Boronic Acids / toxicity
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Fructose / chemistry
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HeLa Cells
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Humans
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Hydrogels
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Rheology
Substances
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Alginates
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Biocompatible Materials
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Boronic Acids
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Hydrogels
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Fructose